报告题目:The C. elegans Taste Receptor Homolog LITE-1 Is a Photoreceptor
报告人:龚建科博士
报告人简介:龚建科,2007年本科毕业于华南农业大学,2010年硕士毕业于华中科技大学,之后在华中科技大学攻读博士学位,期间到美国密歇根大学交换学习,目前在密歇根大学从事博士后研究。
近三年发表的论文:
1. Gong, J., Yuan, Y., Ward, A., Kang, L., Zhang, B., Wu, Z., Peng, J., Feng, Z., Liu, J.,Xu, X.Z.S. (2016) The C. elegans taste receptor homolog LITE-1 is a photoreceptor.
Cell 167, 1252-1263 (Previewed by Science)
2. Li, G., Gong, J., Lei, H., Liu, J., Xu, X.Z.S. (2016) Promotion of behavior and neuronal function by reactive oxygen species in C. elegans. Nature communications 7:13234
3. Chaudhuri, J., Bose, N., Gong, J., Hall, D., Rifkind, A., Bhaumik, D., Peiris, H.,Chamoli, M., Le, H., Liu, J., Lithgow, G., Ramanathan, A., Xu, X.Z.S., Kapahi, P.
(2016) A Caenorhabditis elegans model elucidates a conserved role for TRPA1-Nrf signaling in reactive α-dicarbonyl detoxification. Current Biology 26, 1-12
4. Zhang, B.*, Gong, J.*, Zhang, W., Liu, J., Xu, X.Z.S.(2016) Neuron-gut communications mediated by distinct neuroendocrine signals bi-directionally regulate longevity in C. elegans. Neuron (*co-first authors) (Under Review)
5. Rauthan, M. *, Gong, J. *, Wescott, S., Liu, J., Xu, X.Z.S. (2016) MicroRNA regulation of nicotine-dependent behavior in C. elegans. Cell report (*co-first authors) (Revising)
6. Meng, Z., Gong, J., Chen, Z., Sun, J., Xiao, Y., Wang, L., Li, Y., Liu, J., Xu, X.Z.S, Lin, J. (2016) Glucose sensing by skeletal myocytes couples nutrient signaling to
systemic homeostasis. Nature cell biology (Under Review)
7. Jun, H., Yu, H., Gong, J., Jiang, J., Kim, D., Emont, M., Rainey, W., Gimble, J, Liu, J.,Xu, X.Z.S., Wu, J. (2016) CHRNA2 mediates a beige-fat-selective immune-adipose
interaction in mice and humans. Nature medicine (Revising)
8. Chun, L., Gong, J., Yuan, F., Zhang, B., Liu, H., Zheng, T., Yu, T., Xu, X.Z.S., Liu, J.(2015) Metabotropic GABA signalling modulates longevity in C. elegans. Nature
communications 6:8828
9. Xiao, R., Zhang, B.*, Dong, Y.*, Gong, J.*, Xu, T., Liu, J., and Xu, X.Z.S. (2013) A genetic program promotes C. elegans longevity via a thermosensitive TRP channel. Cell 152, 806-817
报告题目:Crystal structure of RNA polymerase-σ54 and the mechanism of rifampicin inhibition.
报告人:杨云博士
报告人简介:杨云,北京大学在读博士研究生(2017年7月毕业)。2011年本科毕业于北京师范大学生物技术专业。2011-2017年在北京大学王忆平教授的实验室攻读博士研究生。2013-2015年在英国帝国理工张晓东教授的实验室学习两年。在校期间多次获得学校的奖励和奖学金,包括北京大学校长奖学金,北京大学三好学生标兵,北京大学创新奖等。博士期间的研究工作涉及细菌内的信号转导,基因转录,基因表达调控,抗生素作用机理等领域。研究成果发表在Science、Open Biology等国际高水平期刊上。
近三年发表的论文:
1.Yang, Y*., Darbari, V.C*., Zhang, N., Lu, D., Glyde, R., Wang, Y.-P., Winkelman, J.T., Gourse, R.L., Murakami, K.S., Buck, M., Zhang, X. (2015). Structures of the RNA polymerase-σ54 reveal new and conserved regulatory strategies. Science 349, 882-885. (*co-first author)
2.Liu, J., Yang, J., Wen, J., Yang, Y., Wei, X., Zhang, X., and Wang, Y.P. (2014). Mutational analysis of dimeric linkers in peri- and cytoplasmic domains of histidine kinase DctB reveals their functional roles in signal transduction. Open biology 4, 140023.
