报告题目：Hijack of host-derived glucose transporter proteins by Chlamydia trachomatis for supporting its intracellular growth： an implication for treating the intracellular pathogen
报告人：Xiaogang Wang, Ph.D
时间地点：2015.11.19 下午2:30 403-3120学术活动室
报告人简介：
Dr. Wang received his B.S degree in biology from Sichuan University in 2003 and then pursued his Ph.Dstudy at University of Chinese Academy of Science in 2004.After obtaining his Ph.D degree from CAS in 2009, Dr. Wang moved to the University of Kansas Medical Center in US for his first postdoctoral training, where he worked on the molecular pathogenesis of enteric pathogens enterotoxigenicEscherichia coli (ETEC) and enterohaemorrhagicE. coli (EHEC), and host innate immunity. After finishing his first postdoctoral training in 2012, he decided to expand his research acumen into a new model of intracellular pathogenesis-Chlamydia in Dr. Richard Stephens lab, a leading group in the field located in University of California, Berkeley. After finishing his second postdoc training in Berkeley in 2014, he move to the Brigham and Women’s Hospital and Harvard Medical School as a research fellow and expandhis research to the multidrug resistant Staphylococcus aureus with a focus of vaccine development against S. aureus caused infectious diseases.
Recent Publications:
1、Li, X., Wang, X.G., Thompson, C., Park, S., Park, W.B., Faridmoayer, A., Wacker, M., Lee, J.C. (2015) Preclinical Efficacy of Clumping Factor A in Prevention of Staphylococcus aureus Infection. Under review in mBio
2、Wang, X.G., Hybiske, K., Stephens, R.S. (2015)Orchestration of the mammalian glucose transporter proteins-1 and 3 by Chlamydia is required for intracellular growth and infectivity. Submitted
3、Wang, X.G., Hybiske, K., Stephens, R.S. (2015) Direct visualization of the expression and localization of chlamydial effector proteins within infected host cells.Under review in Cellular Microbiology
4、Misawa Y., Kelley, K.A., Wang, X.G., Wang, L.H., Park, W.B., Birtel, J., Saslowsky, D., Lee, J.C. (2015) Staphylococcus aureus Colonization of the Mouse Gastrointestinal Tract is Modulated by Wall Teichoic Acid, Capsule, and Surface Proteins. PLoS Pathogens 11(7): e1005061. doi:10.1371/journal.ppat.1005061
5、Wang, X.*, Schwarzer, C.*, Hybiske, K., Machen T.E., Stephens R.S. 2014. Developmental stage oxidoreductive states of Chlamydia and infected host cells. mBio 5(6):e01924-14. doi:10.1128/mBio.01924-14.
6、Schachter, J., Byrne, G.I., Clarke, I. N., Chernesky, M., Darville, T., Hook, E., Mabey, D., Paavonen, J., Starnbach, M., Stephens, R. S., Timms, P., and Wyrick, P. B. (editors). 2014. Wang, X., and Stephens, R.S.,Bimolecular fluorescence sensor to detect Chlamydia effector-protein localization within infected host cells, in Chlamydial Infections: Proceedings of the Thirteenth International Symposium on Human Chlamydial Infections. International Chlamydia Symposium Publ., San Francisco, CA.
7、Gao, X.F., Wang, X.G., Pham, T.H., Feuerbacher, L.A., Lubos, M.L., Huang, M.Z., Olsen, R.,Mushegian, A., Slawson,C.,Hardwidge, PR. (2013) NleB, a bacterial effector with glycosyltransferase activity, targets GAPDH function to inhibit NFkB activation. Cell Host &Microbe. 13: 87-99.
8、Wang, X.G., Hardwidge, P.R. (2012).EnterotoxigenicEscherichia coliprevents host NF-kB activation by targeting IkBapolyubiquitination. Infection and Immunity. 80: 4417-4425.
9、Wang, X.G., Gao, X.F., Hardwidge, P.R. (2012). Heat-labile enterotoxin-induced activation of NF-κB and MAPK pathways in intestinal epithelial cells impacts enterotoxigenicEscherichia coli (ETEC) adherence. Cellular Microbiology. 14, 1231-1241.