报告题目1：Population and Functional Genomics of Haemophilus parasuis
报告时间、地点：2015年10月15日 13:30 403-3120会议室
报告人： 栾世路
报告人简介：
栾世路, 瑞典Umea大学临床细菌学博士，英国剑桥大学博士后。多年在瑞典 Umea 大学、剑桥大学从事医学研究工作. 研究涵盖Streptococcus agalactiae (Group B streptococcus) 和Haemophilus parauis, 致力于细菌致病机理，疾病分子生物学快速诊断和疫苗研发。
近期发表的论文:
1. Luan SL*, Chaudhuri RR, Peters SE, Mayho M, Weinert LA, Crowther SA, Wang J, Langford PR, Rycroft A, Wren BW, Tucker AW, Maskell DJ. (2013). Generation of a Tn5 transposon library in Haemophilus parasuis and analysis by transposon-directed insertion-site sequencing (TraDIS). (2013).Vet Microbiol. 166(3-4):558-66.
2. Howell KJ, Peters SE, Wang J, Hernandez-Garcia J, Weinert LA, Luan SL, Chaudhuri RR, Angen O, Aragon V, Williamson SM, Parkhill J, Langford PR, Rycroft AN, Wren BW, Maskell DJ, and Tucker AW. (2015). Development of a multiplex PCR for rapid molecular serotyping of Haemophilus parasuis. J Clin Microbiol. (Epub ahead of print)
3. Howell KJ, Weinert LA, Chaudhuri RR, Luan SL, Peters SE, Corander J, Harris D, Angen O, Aragon V, Bensaid A, Williamson SM, Parkhill J, Langford PR, Rycroft AN, Wren BW, Holden MT, Tucker AW and Maskell DJ. (2014). The use of genome wide association methods to investigate pathogenicity, population structure and serovar in Haemophilus parasuis. BMC Genomics. 15(1):1179.
4. Howell KJ, Weinert LA, Luan SL, Peters SE, Chaudhuri RR, Harris D, Angen O, Aragon V, Parkhill J, Langford PR, Rycroft A, Wren BW, Tucker AW, Maskell DJ; on behalf of the BRADP1T Consortium. (2013). Gene content and diversity of the loci encoding biosynthesis of capsular polysaccharides of the fifteen serovar reference strains of Haemophilus parasuis (2013). J Bacteriol. 195(18):4264-73
5. Connick P, Kolappan M, Grawley C, Webber DJ, Patani R, Michell AW, Du MQ, Luan SL, Altmann DR, Thompson AJ, Compston A, Scott MA, Miller DH, Chandran S. Autologous mesenchymal stem cells for the treatment of secondary progressive multiple sclerosis: an open-label phase 2a proof-of-concept study (2012). Lancet Neurol. 11(2):150-6.
6. Connick P, Kolappan M, Patani R, Scott MA, Crawley C, He XL, Richardson K, Barber K, Webber DJ, Wheeler-Kingshott CA, Tozer DJ, Samson RS, Thomas DL, Du MQ, Luan SL, Michell AW, Altmann DR, Thompson AJ, Miller DH, Compston A, Chandran S (2011). The mesenchymal stem cells in multiple sclerosis (MSCIMS) trial protocol and baseline cohort characteristics: an open-label pre-test: post-test study with blinded outcome assessments. Trials. 2;12:62
7. Luan SL, Boulanger E, Ye H, Chanudet E, Johnson N, Hamoudi RA, Bacon CM, Liu H, Huang Y, Said J, Chu P, Clemen CS, Cesarman E, Chadburn A, Isaacson PG, Du MQ (2010). Primary effusion lymphoma: Genomic profiling revealed amplification of SELPLG and CORO1C encoding proteins important for cell migration. J Pathol. 222(2):166-79.
8. Villebeck L, Persson M, Luan SL, Hammarström P, Lindgren M, Jonsson BH (2007). Conformational rearrangements of tail-less complex polypeptide 1 (TCP-1) ring complex (TRiC)-bound actin. Biochemistry 46(17):5083-93.
9. Luan SL*, Granlund M, Sellin M, Lagergard T, Spratt BG, and Norgren M (2005). Multilocus sequence typing of Swedish invasive group B streptococcus isolates indicates a neonatally associated genetic lineage and capsule switching. J Clin Microbiol 43, 3727-3733.
10. Luan SL, Granlund M, and Norgren M (2003). An inserted DNA fragment with plasmid features is uniquely associated with the presence of the GBSi1 group II intron in Streptococcus agalactiae. Gene 312, 305-312.
* 通讯作者
报告题目2：Discovery and hypothesis generation through bioinformatics
报告时间、地点：2015年10月15日 13:30 403-3120会议室
报告人： 杨晓勤
报告人简介：2008年开始在南方医科大学（原第一军医大学）攻读博士学位，期间师从原美国惠氏制药生物信息分析师Shuang Liang教授，主要从事组织特异性基因，疾病与药物关系网络的研究，并开发多个生物学数据库。2012年进入同济大学生物信息系张勇教授课题组进行博士后研究工作，主要从事表观遗传以及二代测序相关生物信息学研究。
近三年发表的论文：
Fei Q*, Yang X*, Jiang H, Wang Q, Yu Y, Chen T, Lu C, Atadja P, Liu X, Li E, Zhang Y, & Shou J. SETDB1 modulates PRC2 activity at developmental regulatory genes independent of H3K9 trimethylation in mouse embryonic stem cells. Genome Research, 2015; 25(9):1325-1335. (*: co-first author)
Liu X*, Yang X*, Chen X, Zhang Y, Pan X, Wang G, & Ye Y. Expression profiling identifies bezafibrate as potential therapeutic drug for lung adenocarcinoma. Journal of Cancer, 2015; 6(12):1214-1221. (*: co-first author)
Yang X, Wang G, Wang Y, & Yue X. Association of metabotropic glutamate receptor 3 gene polymorphisms with schizophrenia risk: evidence from a meta-analysis. Neuropsychiatric Disease and Treatment. 2015 Mar 25;11:823-33.
Fang L, Zhang J, Zhang H, Yang X, Jin X, Zhang L, Skalnik D, Jin Y, Zhang Y, Huang X, Li J, & Wong J. The H3K4 Methyltransferase Set1a Is a Key Oct4 Coactivator Essential for Generation of Oct4 Positive Inner Cell Mass. Stem Cells. Accepted
Yang X, Wang Y, Wang G. Quantitative assessment of the influence of EPHX1 gene polymorphisms and cancer risk: a meta-analysis with 94,213 subjects. Journal of Experimental and Clinical Cancer Research. 2014 Sep 28;33:82.
Wang Q, Huang J, Sun H, Liu J, Wang J, Wang Q, Qin Q, Mei S, Zhao C, Yang X, Liu X, & Zhang Y. (2014). CR Cistrome: a ChIP-Seq database for chromatin regulators and histone modification linkages in human and mouse. Nucleic Acids Research. 2014 Jan;42(Database issue):D450-8.
报告题目3：Capture the underlying evolutionary patterns of viruses with computational methods
报告时间、地点：2015年10月15日 13:30 403-3120会议室
报告人：Dr. Mi Liu
报告人简介：Dr. Liu received her Bachelor’s degree from Southeast University in 2009, and Ph.D from Chinese Academy of Sciences in 2015. During those years as a Ph.D student, Mi Liu’s research was focused on the evolution of viruses, including influenza and ebola viruses, and have published several papers on professional journals.
近三年发表文章：
1 Aiping Wu, Chunhu Su*, Dayan Wang*, Yousong Peng*, Mi Liu, Sha Hua, Tianxian Li, George F. Gao, Hong Tang, Jianzhu Chen, Xiufan Liu, Yuelong Shu, Daxin Peng, Taijiao Jiang. 2013. Sequential Reassortments Underlie Diverse Influenza H7N9 Genotypes in China. Cell Host&Microbe. Volume 14, Issue 4, 16 October 2013, Pages 446–452
2 Lizong Deng, Mi Liu*, Sha Hua*, Yousong Peng, Aiping Wu, F. Xiao-Feng Qin, Genhong Cheng, Taijiao Jiang, Network of co-mutations in Ebola virus genome predicts the disease lethality. Cell research. (2015) 25:753-756. *Co-first author.
3 Mi Liu, Tingrui Song, Sha Hua, Aiping Wu, Taijiao Jiang. Computational analysis of antigenic epitopes of avian influenza A (H7N9) viruses. SCIENCE CHINA Life Sciences. Vol.58, No.7:687-693. July 2015.
4 Mi Liu, Xiang Zhao*, Sha Hua*, Xiangjun Du, Yousong Peng, Xiyan Li, Yu Lan, Dayan Wang, Aiping Wu, Yuelong Shu, Taijiao Jiang. Antigenic patterns and evolution of the human influenza A (H1N1) virus. Scientific Reports. 2015; 5: 14171.
5 Sha Hua, Xiyan Li*, Mi Liu*, Yanhui Cheng, Yousong Peng, Weijuan Huang, Minju Tan, Hejiang Wei, Junfeng Guo, Dayan Wang, Aiping Wu, Yuelong Shu, Taijiao Jiang. Antigenic variation of the human influenza A (H3N2) virus during the 2014-2015 winter season. SCIENCE CHINA Life Sciences. doi: 10.1007/s11427-01504899-z. *Co-first author.